[Recent developments in SARS vaccine studies].
Identifieur interne : 002403 ( Main/Exploration ); précédent : 002402; suivant : 002404[Recent developments in SARS vaccine studies].
Auteurs : Emrah Ruh [Turquie]Source :
- Mikrobiyoloji bulteni [ 0374-9096 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Furets, Humains, Modèles animaux de maladie humaine, Recherche biomédicale (tendances), Syndrome respiratoire aigu sévère (), Vaccination (tendances), Vaccins antiviraux, Vaccins atténués, Vaccins inactivés, Vaccins sous-unitaires, Vaccins synthétiques, Vaccins à ADN, Virus du SRAS (immunologie).
- MESH :
English descriptors
- KwdEn :
- Animals, Biomedical Research (trends), Disease Models, Animal, Ferrets, Humans, SARS Virus (immunology), Severe Acute Respiratory Syndrome (prevention & control), Vaccination (trends), Vaccines, Attenuated, Vaccines, DNA, Vaccines, Inactivated, Vaccines, Subunit, Vaccines, Synthetic, Viral Vaccines.
- MESH :
- chemical : Vaccines, Attenuated, Vaccines, DNA, Vaccines, Inactivated, Vaccines, Subunit, Vaccines, Synthetic, Viral Vaccines.
- immunology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- trends : Biomedical Research, Vaccination.
- Animals, Disease Models, Animal, Ferrets, Humans.
Abstract
Severe acute respiratory syndrome (SARS) caused thousands of human infections worldwide and hundreds of deaths in just a few months. Evidence indicates that SARS coronavirus (SARS-CoV) has been circulating from animals to humans since before the 2002-2003 outbreak, suggesting that another pandemic may occur. This possibility has focused continuous action on SARS vaccine research. Inactivated vaccines, viral and bacterial vector vaccines, recombinant protein vaccines, subunit vaccines, DNA vaccines, and live-attenuated virus vaccines have been studied in different animal models. Although different animal models are used in vaccine studies, the most appropriate model for studying SARS is ferret since it develops the typical clinical signs, viral replication patterns and lung pathology compatible with that of SARS pathogenesis in humans. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Moreover, potential vaccine enhancement of SARS have also been shown in some studies. Data from the studies give an important information of the demand for further vaccine development research, especially focusing on mucosal immunization, T-cell immunity and combinations of heterologous vaccines in prime-boost regimens. In this review article developments on SARS vaccines have been discussed under the light of recent literature.
PubMed: 21064002
Affiliations:
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Le document en format XML
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Anabilim Dalı, Ankara, Türkiye. emrahr@yahoo.com</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Turquie</country><wicri:regionArea>Hacettepe Üniversitesi Tıp Fakütesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author></analytic><series><title level="j">Mikrobiyoloji bulteni</title><idno type="ISSN">0374-9096</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomedical Research (trends)</term><term>Disease Models, Animal</term><term>Ferrets</term><term>Humans</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Vaccination (trends)</term><term>Vaccines, Attenuated</term><term>Vaccines, DNA</term><term>Vaccines, Inactivated</term><term>Vaccines, Subunit</term><term>Vaccines, 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Virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Recherche biomédicale</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Biomedical Research</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Ferrets</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Furets</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term><term>Vaccins sous-unitaires</term><term>Vaccins synthétiques</term><term>Vaccins à ADN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) caused thousands of human infections worldwide and hundreds of deaths in just a few months. Evidence indicates that SARS coronavirus (SARS-CoV) has been circulating from animals to humans since before the 2002-2003 outbreak, suggesting that another pandemic may occur. This possibility has focused continuous action on SARS vaccine research. Inactivated vaccines, viral and bacterial vector vaccines, recombinant protein vaccines, subunit vaccines, DNA vaccines, and live-attenuated virus vaccines have been studied in different animal models. Although different animal models are used in vaccine studies, the most appropriate model for studying SARS is ferret since it develops the typical clinical signs, viral replication patterns and lung pathology compatible with that of SARS pathogenesis in humans. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Moreover, potential vaccine enhancement of SARS have also been shown in some studies. Data from the studies give an important information of the demand for further vaccine development research, especially focusing on mucosal immunization, T-cell immunity and combinations of heterologous vaccines in prime-boost regimens. In this review article developments on SARS vaccines have been discussed under the light of recent literature.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Ruh, Emrah" sort="Ruh, Emrah" uniqKey="Ruh E" first="Emrah" last="Ruh">Emrah Ruh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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